PHARMACEUTICAL ANALYSIS Adaptation of a Color Reaction for Spectrophotometric Determination of Diclofenac Sodium and Piroxicam in Pure Form and in Pharmaceutical Formulations
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چکیده
A simple, sensitive, and convenient spectrophotometric method for the determination of diclofenac sodium and piroxicam in pure form and in pharmaceutical formulations was developed. The method is based on the oxidation of diclofenac sodium or piroxicam by iron(III) in the presence of o-phenanthroline. The formation of tris(o-phenanthroline) iron(II) complex (ferroin) upon the reaction of diclofenac sodium or piroxicam with an iron(III)-o-phenanthroline mixture in acetate buffer solution of
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